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KMID : 0379520210370040395
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한국독성학회지
2021 Volume.37 No. 4 p.395 ~ p.403
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Advantages of omics technology for evaluating cadmium toxicity in zebrafish
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Min Eun-Ki
Lee Ahn-Na
Lee Ji-Young
Shim Il-Seob
Kim Pil-Je
Kim Tae-Young
Kim Ki-Tae
Lee Sang-Kyu
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Abstract
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In the last decade, several advancements have been made in omics technologies and they have been applied extensively in diverse research areas. Especially in toxicological research, omics technology can efficiently and accurately generate relevant data on the molecular dynamics associated with adverse outcomes. Toxicomics is defined as the combination of toxicology and omics technologies and encompasses toxicogenomics, toxicoproteomics, and toxicometabolomics. This paper reviews the trend of applying omics technologies to evaluate cadmium (Cd) toxicity in zebrafish (D. rerio). Cd is a toxic heavy metal posing several environmental concerns; however, it is being used widely in everyday life. Zebrafish embryos and larvae are employed as standard models for many toxicity tests because they share 71.4% genetic homology with humans. This study summarizes the toxicity of Cd on the nerves, liver, heart, skeleton, etc. of zebrafish and introduces detailed omics techniques to understand the results of the toxicomic studies. Finally, the trend of toxicity evaluation in the zebrafish model of Cd based on omics technology is presented.
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KEYWORD
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Cadmium, Zebrafish, Toxicogenomics, Toxicoproteomics, Toxicometabolomics
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